MBX-8025 (sodium salt)

MBX-8025 is an agonist of peroxisome proliferator-activated receptor delta (PPARdelta). It is greater than 750- and 2,500-fold selective for PPARdelta over PPARalpha and PPARgamma. MBX-8025 (10 mg/kg per day for eight weeks) reduces increases in fasting blood glucose and serum insulin levels, and decreases insulin resistance in Alms1 mutant (foz/foz) mice fed an atherogenic diet as a model of diet-induced obesity, type 2 diabetes, and non-alcoholic steatohepatitis (NASH). It also decreases serum alanine transaminase (ALT), as well as serum and hepatic cholesterol and triglyceride, levels and reduces markers of NASH in the same model.Formal Name: (R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetate, monosodium salt. Molecular Formula: C21H22F3O5S . Na. Formula Weight: 466.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Acetonitrile: Slightly soluble, DMSO: Slightly soluble, PBS (pH 7.2): Slightly soluble. lambdamax: 229, 258 nm. SMILES: FC(F)(F)C1=CC=C(OC[C@@H](OCC)CSC2=CC=C(OCC([O-])=O)C(C)=C2)C=C1.[Na+]. InChi Code: InChI=1S/C21H23F3O5S.Na/c1-3-27-17(11-28-16-6-4-15(5-7-16)21(22,23)24)13-30-18-8-9-19(14(2)10-18)29-12-20(25)26,/h4-10,17H,3,11-13H2,1-2H3,(H,25,26),/q,+1/p-1/t17-,/m1./s1. InChi Key: XCAXFCPCOXDEHC-UNTBIKODSA-M.