MB710

A stabilizer of mutant p53, increases the thermal stability and inhibits aggregation of the mutant p53Y220C DNA-binding domain (Kd = 4 µM), selectively inhibits growth of NUGC-3 cells expressing p53Y220C over WI38 cells that do not express the p53Y220C mutant (IC50s = 90 and >120 µM, respectively), selectively reduces the viability of Huh7 p53Y220C-expressing cells over Huh7 p53-/- cells at 90 and 120 µM, respectively. SMILES: O=C(C1=C2N=C(N(CC)CC)SC2=C(N3C=CC=C3)C(I)=C1O)O. InChi Code: InChI=1S/C16H16IN3O3S/c1-3-19(4-2)16-18-11-9(15(22)23)13(21)10(17)12(14(11)24-16)20-7-5-6-8-20/h5-8,21H,3-4H2,1-2H3,(H,22,23). InChi Key: SEBJATZOIHUGAU-UHFFFAOYSA-N