M435-1279

M435-1279 is an inhibitor of ubiquitin-conjugating enzyme E2T (UBE2T). It binds to UBE2T (Kd = 50.5 µM), inhibits UBE2T-mediated degradation of receptor for activated C kinase 1 (RACK1), and reduces hyperactive Wnt/beta-catenin signaling. M435-1279 reduces the viability of MKN45 and AGS gastric cancer cells when used at concentrations ranging from 4 to 32 µM. Intratumoral administration of M435-1279 (5 mg/kg per day) reduces tumor growth in an MKN45 mouse xenograft model.. SMILES: O=C(C1=C(O)C2=C(SC3=C2CCCC3)NC1=O)NC4=CC=C(S(=O)(N)=O)C=C4. InChi Code: InChI=1S/C18H17N3O5S2/c19-28(25,26)10-7-5-9(6-8-10)20-16(23)14-15(22)13-11-3-1-2-4-12(11)27-18(13)21-17(14)24/h5-8H,1-4H2,(H,20,23)(H2,19,25,26)(H2,21,22,24). InChi Key: MVQJFYRZMPKNIV-UHFFFAOYSA-N