M1001

M1001 is a modulator of hypoxia-inducible factor-2alpha (HIF-2alpha). It stabilizes the aryl hydrocarbon receptor nuclear translocator (ARNT) and HIF-2alpha protein-protein interaction and promotes the gene expression of HIF-2alpha targets VEGF-A, CCND1, SLC2A1, and NDRG1, in 786-O cells when used at a concentration of 10 µM.Formal Name: N-[2-(1-pyrrolidinyl)phenyl]-1,2-benzisothiazol-3-amine, 1,1-dioxide. CAS Number: 874590-32-6. Molecular Formula: C17H17N3O2S. Formula Weight: 327.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 15 mg/ml, DMSO: 10 mg/ml. lambdamax: 210, 255 nm. SMILES: O=S1(N=C(C2=C1C=CC=C2)NC3=C(N4CCCC4)C=CC=C3)=O. InChi Code: InChI=1S/C17H17N3O2S/c21-23(22)16-10-4-1-7-13(16)17(19-23)18-14-8-2-3-9-15(14)20-11-5-6-12-20/h1-4,7-10H,5-6,11-12H2,(H,18,19). InChi Key: LONXCUOJVJLTIP-UHFFFAOYSA-N.