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A Pim-3 kinase inhibitor (IC50 = 0.05 µM), selective for Pim-3 over Pim-1 and Pim-2 (IC50s = 2.5 µM for both), inhibits the growth of DU145 and MIA PaCa-2 cells (IC50s = 0.9 and 3.9 µM, respectively), inhibits IL-6-induced STAT3 phosphorylation in DU145 cells at 10 µM. Formulation: A solid. InChI: InChI=1S/C22H28ClN5O3/c1-2-19(18-5-4-17(23)15-20(18)29)26-27-22(30)16-6-8-25-21(14-16)24-7-3-9-28-10-12-31-13-11-28/h4-6,8,14-15,29H,2-3,7,9-13H2,1H3,(H,24,25)(H,27,30). InChIKey: FXXCNYVQIONABS-UHFFFAOYSA-N. SMILES: O=C(C1=CC=NC(NCCCN2CCOCC2)=C1)NN=C(CC)C3=CC=C(C=C3O)Cl
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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