LY456236 (hydrochloride)

An antagonist of mGluR1 (IC50 = 140 nM), reduces the growth of PC-9 cells and PC-9-AMG cells in MGS co-culture but not in monoculture, reduces MGS co-culture-induced increases in EGFR levels in PC-9-AMG cells, reduces tumor growth in a PC-9-AMG mouse model of brain metastasis at 50 mg/kg per day, inhibits seizures in a variety of seizure models, including inhibition of audiogenic clonic-tonic seizures in mice (ED50 = 35 mg/kg), reduces second-phase, but not first-phase, formalin-induced hyperalgesia at 30 and 100 mg/kg. Formulation: A solid. InChI: InChI=1S/C16H15N3O2.ClH/c1-20-12-5-3-11(4-6-12)19-16-14-9-13(21-2)7-8-15(14)17-10-18-16,/h3-10H,1-2H3,(H,17,18,19),1H. InChIKey: AVKFOWUSTVWZQN-UHFFFAOYSA-N. SMILES: COC(C=C1)=CC=C1NC(N=CN=C2C=C3)=C2C=C3OC.Cl