An antagonist of mGluR1 (IC50 = 140 nM), reduces the growth of PC-9 cells and PC-9-AMG cells in MGS co-culture but not in monoculture, reduces MGS co-culture-induced increases in EGFR levels in PC-9-AMG cells, reduces tumor growth in a PC-9-AMG mouse model of brain metastasis at 50 mg/kg per day, inhibits seizures...

Description: LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective, non-competitive and oral activity, and can inhibit the hydrolysis of inositol phosphate with IC50 of 0.145 µM. LY 456236 hydrochloride inhibited EGFR with IC50 of 0.91 µM....