LY294002

LY294002 is a multi-kinase inhibitor. It inhibits casein kinase 2 (CK2, IC50 = 0.098 µM), the PI3K subunits p110alpha, p110beta, p110delta, and p110gamma (IC50s = 0.497, 0.554, 0.331, and 3.8 µM, respectively), and DNA protein kinase (DNA-PK, IC50 = 6 µM), among other kinases, as well as CK1, GSK3alpha, and GSK3beta by greater than 40% at 10 µM. LY294002 (12.5, 25, and 50 µM) reduces viability of SGC-7901 human gastric cancer cells. It induces apoptosis and autophagy in SGC-7901 cells when used at a concentration of 50 µM. LY294002 (2 ng/ml/kg) reduces tumor volume in DLD-1 and LoVo mouse xenograft models. It also reduces aging-induced increases in the number of aging human vascular smooth muscle cells (VSMCs) positive for senescence-associated beta-galactosidase (SA-beta-gal) when used at a concentration of 20 µM in the 5th to 15th generations.Formal Name: 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one. CAS Number: 154447-36-6. Synonyms: NSC 697286. Molecular Formula: C19H17NO3. Formula Weight: 307.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: acidic PBS: <50 µg/ml, basic PBS: <50 µg/ml, DMF: >25 mg/ml, DMSO: >36 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: >16.5 mg/ml, PBS pH 7.2: <50 µg/ml. lambdamax: 223, 302 nm. SMILES: O=c1cc(oc2c(cccc12)c1ccccc1)N1CCOCC1. InChi Code: InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2. InChi Key: CZQHHVNHHHRRDU-UHFFFAOYSA-N.