LXS-196

LXS-196 is a PKC inhibitor (IC50s = 1.9 and 0.4 nM for PKCalpha and PKCtheta, respectively). It is selective for PKCalpha and PKCtheta over GSK3beta (IC50 = 3,100 nM). It inhibits proliferation of TMD8 B cell lymphoma and 92.1 uveal melanoma cells (IC50s = 900 and 184 nM, respectively) but not SK-MEL-28 skin melanoma cells (IC50 = >10,000 nM).Formal Name: 3-amino-N-[3-(4-amino-4-methyl-1-piperidinyl)-2-pyridinyl]-6-[3-(trifluoromethyl)-2-pyridinyl]-2-pyrazinecarboxamide. CAS Number: 1874276-76-2. Molecular Formula: C22H23F3N8O. Formula Weight: 472.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml. lambdamax: 288, 375 nm. SMILES: O=C(C1=C(N)N=CC(C2=C(C(F)(F)F)C=CC=N2)=N1)NC3=NC=CC=C3N4CCC(C)(CC4)N. InChi Code: InChI=1S/C22H23F3N8O/c1-21(27)6-10-33(11-7-21)15-5-3-9-29-19(15)32-20(34)17-18(26)30-12-14(31-17)16-13(22(23,24)25)4-2-8-28-16/h2-5,8-9,12H,6-7,10-11,27H2,1H3,(H2,26,30)(H,29,32,34). InChi Key: XXJXHXJWQSCNPX-UHFFFAOYSA-N.