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Lovastatin is a fungal metabolite that has been found in A. terreus and an inhibitor of HMG-CoA... more
Product information "Lovastatin"
Lovastatin is a fungal metabolite that has been found in A. terreus and an inhibitor of HMG-CoA reductase (Ki = 1.4 nM). It is also a prodrug form of the HMG-CoA reductase inhibitor lovastatin hydroxy acid (Cay-10010339). Lovastatin (8 mg/kg per day) reduces plasma cholesterol levels in dogs. It suppresses TNF-induced NF-kappaB activation (IC50 = ~15 µM) and potentiates apoptosis in human myeloid leukemia cells. Lovastatin also increases cellular lipid peroxidation and decreases glutathione peroxidase 4 (GPX4) levels in cancer cells. Formulations containing lovastatin have been used in the treatment of hypercholesterolemia.Formal Name: 2S-methyl-butanoic acid, 1S,2,3R,7S,8S,8aR-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester. CAS Number: 75330-75-5. Synonyms: (+)-Mevinolin, Monacolin K, NSC 633781. Molecular Formula: C24H36O5. Formula Weight: 404.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 20 mg/ml. lambdamax: 238 nm. SMILES: C[C@@H]1C[C@H](OC([C@@H](C)CC)=O)[C@@]2([H])C(C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(O3)=O)=C1. InChi Code: InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1. InChi Key: PCZOHLXUXFIOCF-BXMDZJJMSA-N. Origin: Synthetic.
Keywords: | 2S-methyl-butanoic acid, 1S,2,3R,7S,8S,8aR-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10010338 |
Properties
Application: | NF-kappaB activation inhibitor |
MW: | 404.5 D |
Formula: | C24H36O5 |
Purity: | >98% |
Format: | Crystalline Solid |
Database Information
CAS : | 75330-75-5| Matching products |
KEGG ID : | K00021 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H317, H351, H361 |
P Phrases: | P201, P202, P261, P272, P280, P321, P302+P352, P308+P313, P333+P313, P362+P364, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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