Lovastatin

Lovastatin
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010338-5 5 mg -

6 - 10 business days*

25.00€
Cay10010338-10 10 mg -

6 - 10 business days*

38.00€
Cay10010338-50 50 mg -

6 - 10 business days*

88.00€
 
Lovastatin is an HMG-CoA reductase inhibitor that was initially isolated from A. terreus. It is a... more
Product information "Lovastatin"
Lovastatin is an HMG-CoA reductase inhibitor that was initially isolated from A. terreus. It is a prodrug of its more potent metabolite, lovastatin hydroxy acid (Cay-10010339). Both competitively inhibit HMG-CoA reductase with Ki values of 1.4 and 0.6 nM for lovastatin and the open ring, hydroxy acid form, respectively. Lovastatin (8 mg/kg/day) reduces plasma cholesterol in dogs by 29% over a three week period. It also suppresses TNF-induced NF-kappaB activation (IC50 ~ 15 µM), which potentiates apoptosis in human myeloid leukemia cells and thus, may be useful in treating cancer. Formulations containing lovastatin were the first HMG-CoA reductase inhibitors to be used in the treatment of hypercholesterolemia. Formal Name: 2S-methyl-butanoic acid, 1S,2,3R,7S,8S,8aR-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester. CAS Number: 75330-75-5. Molecular Formula: C24H36O5. Formula Weight: 404.5. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 20 mg/ml. lambdamax: 238 nm. SMILES: C[C@@H]1C[C@H](OC([C@@H](C)CC)=O)[C@@]2([H])C(C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(O3)=O)=C1. InChi Code: InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1. InChi Key: PCZOHLXUXFIOCF-BXMDZJJMSA-N.
Keywords: 2S-methyl-butanoic acid, 1S,2,3R,7S,8S,8aR-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
Supplier: Cayman Chemical
Supplier-Nr: 10010338

Properties

Application: NF-kappaB activation inhibitor
MW: 404.5 D
Formula: C24H36O5
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 75330-75-5| Find alternatives
KEGG ID : K00021 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H317, H351, H361
P Phrases: P201, P202, P261, P272, P280, P302+352, P308+313, P321, P333+313, P362+364, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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