Lofepramine
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You can also order by e-mail: info@biomol.com
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Lofepramine (Leo 640) is a potent tricyclic antidepressant that is extensively... more
Product information "Lofepramine"
Description: Lofepramine (Leo 640) is a potent tricyclic antidepressant that is extensively metabolized to desipramine. It inhibits the serotonin and norepinephrine transporters by inhibiting neurons with Kd values of 70 and 5.4 nM, respectively, with weak antagonism of serotonin, histamine and muscarinic receptors. Target: 5-HT Receptor, Norepinephrine. Smiles: C(CCN(CC(=O)C1=CC=C(Cl)C=C1)C)N2C=3C(CCC=4C2=CC=CC4)=CC=CC3. References: Lancaster SG, et al. Lofepramine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs. 1989 Feb,37(2):123-40.
| Keywords: | Lopramine, Amplit, Leo 640, Gamanil |
| Supplier: | TargetMol |
| Supplier-Nr: | T15773 |
Properties
| Application: | Targets solute carrier family 6 (neurotransmitter transporter, serotonin) member 4 (SLC6A4, SERT) |
| MW: | 418.96 D |
| Formula: | C26H27ClN2O |
Database Information
| CAS : | 23047-25-8| Matching products |
| KEGG ID : | K05035 | Matching products |
| Protein Atlas Nr. : | Neuropharmacologics/Ion Channel Modulators |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H336, H370, H373 |
| P Phrases: | P260, P261, P264, P270, P271, P312, P314, P321, P304+P340, P308+P311, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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