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You can also order by e-mail: info@biomol.com
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You can also order by e-mail: info@biomol.com
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Linopirdine is an enhancer of the stimulus-evoked but not basal release of several... more
Product information "Linopirdine"
Linopirdine is an enhancer of the stimulus-evoked but not basal release of several neurotransmitters, including acetylcholine, dopamine, serotonin, and glutamate. It increases acetylcholine release in rat hippocampal CA1 neurons by blocking voltage-gated, calcium-activated and leak (M-type, Kv7.2/7.3, KCNQ2/3) K+ current with an IC50 value of 2.4 µM. Inhibition of M-channels is reported to result in the depolarization of CA3 pyramidal neurons and activated presynaptic voltage-gated P/Q- and N-type calcium channels, which leads to Ca2+ influx and increased neurotransmitter release. Linopirdine has been shown to produce a number of effects including EEG patterns of enhanced vigilance, induction of c-fos expression in cerebral cortex, reduction of the increase of cerebral glucose utilization induced by hypoxia, and improved performance in animal models of learning and memory. Linopirdine has also been identified as an agonist of transient receptor potential vanilloid type 1 (EC50 = 115 µM in HEK293 cells voltage clamped at -60 mV).Formal Name: 1,3-dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one. CAS Number: 105431-72-9. Synonyms: DuP-996. Molecular Formula: C26H21N3O. Formula Weight: 391.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMSO: 25 mg/mL, Ethanol: 30 mg/mL, Ethanol:PBS (pH 7.2) (1:30): 0.03 mg/mL. lambdamax: 248 nm. SMILES: O=C1C(CC2=CC=NC=C2)(CC3=CC=NC=C3)C4=CC=CC=C4N1C5=CC=CC=C5. InChi Code: InChI=1S/C26H21N3O/c30-25-26(18-20-10-14-27-15-11-20,19-21-12-16-28-17-13-21)23-8-4-5-9-24(23)29(25)22-6-2-1-3-7-22/h1-17H,18-19H2. InChi Key: YEJCDKJIEMIWRQ-UHFFFAOYSA-N.
Keywords: | DuP-996, 1,3-dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one |
Supplier: | Cayman Chemical |
Supplier-Nr: | 19547 |
Properties
Application: | Nootropic, Cognition enhancer |
MW: | 391.5 D |
Formula: | C26H21N3O |
Purity: | >98% |
Format: | Crystalline Solid |
Database Information
CAS : | 105431-72-9| Matching products |
KEGG ID : | K04927 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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