Lidocaine-d10

Lidocaine-d10 is intended for use as an internal standard for the quantification of lidocaine by GC- or LC-MS. Lidocaine is an inhibitor of voltage-gated sodium channels (Navs) and a local anesthetic. It inhibits Nav1.2 (Ki = 11 µM), adult and neonatal Nav1.5 (IC50s = 380.1 and 360 µM, respectively), and Nav1.7 and Nav1.8 channels (IC50s = 450 and 104 µM, respectively) expressed in Xenopus oocytes. Topical administration of lidocaine (1-2%) reduces escape behavior in a rhesus monkey model of noxious electrical cutaneous pain. Formulations containing lidocaine have been used as local and regional anesthetics.Formal Name: 2-[di(ethyl-d5)amino]-N-(2,6-dimethylphenyl)-acetamide. CAS Number: 851528-09-1. Molecular Formula: C14H12D10N2O. Formula Weight: 244.4. Purity: >99% deuterated forms (d1-d10). Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. SMILES: [2H]C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C([2H])([2H])[2H])CC(N(C1=C(C)C=CC=C1C)[H])=O. InChi Code: InChI=1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)/i1D3,2D3,5D2,6D2. InChi Key: NNJVILVZKWQKPM-JKSUIMTKSA-N.