Leriglitazone

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
TGM-T15736-1mg	1 mg				7 - 10 business days*		651.00€
TGM-T15736-5mg	5 mg				7 - 10 business days*		1,877.00€

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Description: Leriglitazone, a metabolite of pioglitazone, binds to the PPARgamma C-terminal... more

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Product information "Leriglitazone"

Description: Leriglitazone, a metabolite of pioglitazone, binds to the PPARgamma C-terminal ligand-binding domain (Ki: 1.2 µM) and induces transcriptional efficacy of the PPARgamma (EC50: 680 nM). Leriglitazone PioOH is a PPARgamma agonist, stabilizes the PPARgamma activation function-2 (AF-2) co-activator binding surface. Target: Others. Smiles: O=C1SC(C(=O)N1)CC2=CC=C(OCCC3=NC=C(C=C3)C(O)C)C=C2. References: Mosure SA,et al. Structural Basis of Altered Potency and Efficacy Displayed by a Major in Vivo Metabolite of the Antidiabetic PPARgamma Drug Pioglitazone. J Med Chem. 2019 Feb 28,62(4):2008-2023.

Keywords:	Hydroxypioglitazone
Supplier:	TargetMol
Supplier-Nr:	T15736

Properties

Application:	Targets peroxisome proliferator-activated receptor gamma (NR1C3, PPARG)
MW:	372.44 D
Formula:	C19H20N2O4S
Format:	32160405

Database Information

CAS :	146062-44-4\| Matching products
KEGG ID :	K08530 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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