Leelamine hydrochloride

Description: Leelamine hydrochloride, a tricyclic diterpene extracted from pine tree bark, inhibits the transcriptional activity of the androgen receptor, known to regulate fatty acid synthesis [2,3]. This compound acts as a cannabinoid receptor type 1 (CB1) agonist and suppresses SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells, irrespective of androgen receptor status. Target: Others. Smiles: C[C@@]12C=3C(CC[C@]1([C@@](CN)(C)CCC2)[H])=CC(C(C)C)=CC3.Cl. References: Kuzu OF, et al. Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport. Mol Cancer Ther. 2014 Jul,13(7):1690-703.