Lanicemine (hydrochloride)

Lanicemine is a low-trapping NMDA receptor antagonist (IC50 = 9. µM) and an active metabolite of BHV 5000. Intraperitoneal administration of lanicemine prevents seizures induced by maximal electroshock, 4-aminopyridine (Cay-18511), N-methyl-DL-aspartate, or kainic acid in mice (ED50s = 13, 17. 54, and ~50 mg/kg, respectively). Lanicemine (24 mg/kg, p.o.) decreases hippocampal neuronal damage in a rat model of global ischemia induced by four-vessel occlusion. It decreases immobility time in the tail suspension test in mice, an effect that is enhanced by hyperforin (Cay-19572). Formal Name: alpha-phenyl-2-pyridineethanamine, dihydrochloride. CAS Number: 153322-06-6. Synonyms: ARL 15896AR AR-R 15896AR AZD 6765 BHV 5500. Molecular Formula: C13H14N2  2HCl. Formula Weight: 271.2. Purity: >95%. Formulation (Request formulation change): A solid. Solubility: DMSO: Slightly soluble: 0.1-1 mg/ml PBS (pH 7.2): Soluble: > 10 mg/ml. SMILES: N[C@H](C1=CC=CC=C1)CC2=CC=CC=N2.Cl.Cl. InChi Code: InChI=1S/C13H14N2.2ClH/c14-13(11-6-2-1-3-7-11)10-12-8-4-5-9-15-12../h1-9,13H,10,14H2.2*1H/t13-../m0../s1. InChi Key: KHJHFYAGQZYCLC-GXKRWWSZSA-N. Storage: -20°C. Stability: > 4 years.