Lanepitant (hydrochloride)

Lanepitant is a neurokinin-1 (NK1) receptor antagonist (Ki = 0. nM). It inhibits Ac-[Arg6,Sar9,Met(O2)11]-substance P6-11-induced increases in tail biting and scratching in mice when administered at doses of 1, 5, or 10 mg/kg. Lanepitant (10 mg/kg) inhibits late-phase formalin-induced increases in paw licking in mice. It reduces corneal opacity and neovascularization and decreases leukocyte infiltration in a mouse model of alkali burn-induced corneal damage when topically applied at a concentration of 6. mg/ml six times per day.. Solulibility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml: Water: Slightly soluble: 0.1-1 mg/ml.