L-Allylglycine

L-Allylglycine is an amino acid derivative that reduces glutamate decarboxylase (GAD) activity by 60% when administered at a dose of 39.8 µmol/g per hour ex vivo in mouse brain preparations. L-Allylglycine (1.2 mmol/kg, i.p.) induces convulsions and decreases GABA concentration throughout the cerebellum, pons, medulla, striatum, cortex, and hippocampus in mice. Chronic administration (3.2 µg/0.5 µl per hour for 13 days) of L-allylglycine in rats increases locomotor activity in an open field test and impairs attention in the 5-choice serial reaction time task (5CSRTT). In vitro, L-allylglycine inhibits GAD only when used at high concentrations (1-80 mM). The more potent in vivo activity can be attributed to metabolic conversion of L-allylglycine to 2-keto-4-pentanoic acid, a more potent convulsant and GAD inhibitor.Formal Name: 2S-amino-4-pentenoic acid. CAS Number: 16338-48-0. Molecular Formula: C5H9NO2. Formula Weight: 115.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Ethanol: Insoluble, PBS (pH 7.2): 10 mg/ml. SMILES: OC([C@@H](N)CC=C)=O. InChi Code: InChI=1S/C5H9NO2/c1-2-3-4(6)5(7)8/h2,4H,1,3,6H2,(H,7,8)/t4-/m0/s1. InChi Key: WNNNWFKQCKFSDK-BYPYZUCNSA-N.