L-Allylglycine is an amino acid derivative that reduces glutamate decarboxylase (GAD) activity by 60% when administered at a dose of 39.8 µmol/g per hour ex vivo in mouse brain preparations. L-Allylglycine (1.2 mmol/kg, i.p.) induces convulsions and decreases GABA concentration throughout the cerebellum, pons,...

Description: L-Allylglycine is a potent inhibitor of the synthetic enzyme for GABA, glutamic acid decarboxylase. Target: GABA Receptor, Dehydrogenase. Smiles: N[C@@H](CC=C)C(O)=O. References: Abshire VM, et al. Injection of L-allylglycine into the posterior hypothalamus in rats causes decreases in local GABA which...

Amino acids are the basic units of proteins, which are linked by peptide bonds to form polypeptide chains that fold into proteins with specific functions. There are 20 common standard amino acids in nature, primarily distinguished by their side chains (R-groups). These differences give amino acids different...