L-156,602

L-156,602 is an antagonist of the complement component 5A (C5a) receptor (IC50 = 1.7 µg/L in a radioligand binding assay using neutrophil membranes). It is also a cyclic depsipeptide antibiotic that is active against Gram-positive bacteria. L-156,602 has anti-inflammatory activity in mice, decreasing inflammation induced by muramyl dipeptide (MDP) when administered at a dose of 0.5 mg/kg and by concanavalin A (Cay-14951) at doses of 0.25 and 0.5 mg/kg.Formal Name: (3S)-3-hydroxy-N-[(2S)-2-hydroxy-1-oxo-2-[(2R,5R,6R)-tetrahydro-2-hydroxy-6-methyl-5-[(2S)-2-methylbutyl]-2H-pyran-2-yl]propyl]-L-leucyl-(3R)-hexahydro-3-pyridazinecarbonyl-N-hydroxy-L-alanylglycyl-(3S)-hexahydro-3-pyridazinecarbonyl-N-hydroxy-D-alanine, (6->13)-lactone. CAS Number: 125228-51-5. Synonyms: PD 124966. Molecular Formula: C38H64N8O13. Formula Weight: 841.0. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble. SMILES: O=C(CNC([C@H](C)N(O)C([C@](CCCN1)([H])N1C([C@](NC([C@](O)(C)[C@@]2(O)CC[C@H](C[C@@H](C)CC)[C@@H](C)O2)=O)([H])[C@H](C(C)C)OC([C@@H](C)N3O)=O)=O)=O)=O)N4[C@](CCCN4)([H])C3=O. InChi Code: InChI=1S/C38H64N8O13/c1-9-21(4)18-25-14-15-38(55,59-24(25)7)37(8,54)36(53)42-29-30(20(2)3)58-35(52)23(6)46(57)32(49)26-12-10-16-40-43(26)28(47)19-39-31(48)22(5)45(56)33(50)27-13-11-17-41-44(27)34(29)51/h20-27,29-30,40-41,54-57H,9-19H2,1-8H3,(H,39,48)(H,42,53)/t21-,22-,23+,24+,25+,26-,27+,29-,30-,37+,38+/m0/s1. InChi Key: ZJZOPNINWIGNQW-SYYWPETLSA-N. Origin: Bacterium/Streptomyces sp..