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An ALDH1A3 inhibitor (IC50 = 5.14 nM), potentiates glucose-induced insulin secretion from pancreatic islets isolated from patients with type 2 diabetes at 10 µM, decreases plasma insulin levels and reduces blood glucose levels in an IPGTT in diabetic db/db male mice at 40 mg/kg per day, decreases blood glucose levels and increases plasma insulin levels in a mouse model of high-fat diet-induced obesity at 270 ppm in the diet. Formulation: A solid. InChI: InChI=1S/C17H16FN3O2/c1-2-10-9-19-6-5-12(10)17(23)21-15-7-11-3-4-16(22)20-14(11)8-13(15)18/h5-9H,2-4H2,1H3,(H,20,22)(H,21,23). InChIKey: QJJWNFKDFKNPEV-UHFFFAOYSA-N. SMILES: FC1=C(C=C2C(NC(CC2)=O)=C1)NC(C3=C(CC)C=NC=C3)=O
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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