KC7F2

Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor composed of a HIF-1alpha subunit and HIF-1beta subunit. The HIF-1alpha subunit is regulated by cellular oxygen levels and therefore plays an important role in maintaining cellular oxygen homeostasis. KC7F2 is an inhibitor of HIF-1alpha protein translation, but not transcription, that suppresses phosphorylation of two key regulators of protein synthesis, eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and p70 S6 kinase (S6K). It inhibits hypoxia-induced expression of several HIF target genes, such as carbonic anhydrase IX, matrix metalloproteinase 2, enolase 1, and endothelin 1. KC7F2 is cytotoxic to a variety of cancer cell lines with an IC50 value of 15-25 µM.Formal Name: N,N'-(dithiodi-2,1-ethanediyl)bis[2,5-dichloro]-benzenesulfonamide. CAS Number: 927822-86-4. Molecular Formula: C16H16Cl4N2O4S4. Formula Weight: 570.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml, DMSO: 14 mg/ml. SMILES: ClC1=C(S(NCCSSCCNS(C2=C(Cl)C=CC(Cl)=C2)(=O)=O)(=O)=O)C=C(Cl)C=C1. InChi Code: InChI=1S/C16H16Cl4N2O4S4/c17-11-1-3-13(19)15(9-11)29(23,24)21-5-7-27-28-8-6-22-30(25,26)16-10-12(18)2-4-14(16)20/h1-4,9-10,21-22H,5-8H2. InChi Key: REQLACDIZMLXIC-UHFFFAOYSA-N.