JK-P3

JK-P3 is an inhibitor of the tyrosine kinases VEGFR2, FGFR1, and FGFR3 (IC50s = 7.83, 27, and 5.18 µM, respectively). It decreases VEGF-A-induced VEGFR2 phosphorylation in human umbilical vein endothelial cells (HUVECs) when used at a concentration 10 µM. JK-P3 decreases the proliferation of HCT116, SW480, and HT-29 colon cancer cells (IC50s = 24.26, 27.2, and 29.65 µM, respectively), as well as A549 lung cancer cells (IC50 = 30.49 µM). It decreases wound closure percentage in a scratch assay, as well as endothelial branch length and branch points formed by VEGF-A-stimulated HUVECs when used at a concentration of 10 µM.Formal Name: 3,4-dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide. CAS Number: 942655-44-9. Molecular Formula: C18H17N3O3. Formula Weight: 323.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml. SMILES: O=C(C1=CC=C(C(OC)=C1)OC)NC2=NNC(C3=CC=CC=C3)=C2. InChi Code: InChI=1S/C18H17N3O3/c1-23-15-9-8-13(10-16(15)24-2)18(22)19-17-11-14(20-21-17)12-6-4-3-5-7-12/h3-11H,1-2H3,(H2,19,20,21,22). InChi Key: QAZJUVDICQNITG-UHFFFAOYSA-N.