JH-X-119-01
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
JH-X-119-01 is a covalent inhibitor of IL-1 receptor-associated kinase 1 (IRAK1, IC50 = 9 nM). It... more
Product information "JH-X-119-01"
JH-X-119-01 is a covalent inhibitor of IL-1 receptor-associated kinase 1 (IRAK1, IC50 = 9 nM). It is selective for IRAK1 over IRAK4 (IC50 = >10,000 nM). JH-X-119-01 is cytotoxic against a panel of mutant MyD88-expressing Waldenstrom's macroglobulinemia (WM), ABC subtype diffuse large B cell lymphoma (DLBCL), and lymphoma cells (EC50s = 0.59-9. µM). It has a synergistic cytotoxic effect in MyD88-mutant-expressing BCWM. WM and TMD8 ABC DLBCL cells when used in combination with ibrutinib (Cay-16274). JH-X-119-01 (5 and 10 mg/kg) also reduces lung injury and increases survival in a mouse model of LPS-induced sepsis.. Solulibility: DMSO: Sparingly soluble: 1-10 mg/mL: PBS (pH 7.2): Insouble.
| Keywords: | N-[4-[[3-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]phenyl]-6-(1H-pyrazol-3-yl)-2-pyridinecarboxamide |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 43041 |
Properties
| Application: | Covalent IRAK1 inhibitor |
| MW: | 452.47 D |
| Formula: | C25H20N6O3 |
| Purity: | >95% |
| Format: | Solid |
Database Information
| CAS : | 2227368-54-7| Matching products |
| KEGG ID : | K04730 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | -20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
|
| H Phrases: | H315, H319 |
| P Phrases: | P264, P280, P302+352, P305+351+338, P321, P332+313, P337+313, P362+364 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed