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Item number: Cay43041-5

JH-X-119-01 is a covalent inhibitor of IL-1 receptor-associated kinase 1 (IRAK1, IC50 = 9 nM). It is selective for IRAK1 over IRAK4 (IC50 = >10,000 nM). JH-X-119-01 is cytotoxic against a panel of mutant MyD88-expressing Waldenstrom's macroglobulinemia (WM), ABC subtype diffuse large B cell lymphoma (DLBCL), and...

Keywords:	N-[4-[[3-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]phenyl]-6-(1H-pyrazol-3-yl)-2-pyridinecarboxamide
Application:	Covalent IRAK1 inhibitor
CAS	2227368-54-7
MW:	452.47 D

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JH-X-119-01

Item number: TGM-T9203-100mg

Description: JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1 (Interleukin-1 Receptor-Associated Kinase 1). Target: IRAK. Smiles: C=CC(=O)Nc1cccc(c1)C(=O)Nc1ccc(NC(=O)c2cccc(n2)-c2cc[nH]n2)cc1. References: John M Hatcher, et al.ACS Med Chem Lett.2020 Oct 9,11(11):2238-2243.

CAS	2227368-54-7
MW:	452.46 D

From 57.00€ *

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