IWR-1-endo

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
AG-CR1-3581-M005	5 mg		-		3 - 9 business days*		88.00€

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Synthetic. Potent and reversible cell permeable Wnt pathway signaling inhibitor. Inhibits... more

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Product information "IWR-1-endo"

Synthetic. Potent and reversible cell permeable Wnt pathway signaling inhibitor. Inhibits Wnt-induced accumulation of beta-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, CK1 and GSK-3beta. Stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK-3beta. Tankyrase-1 (TNKS1/PARP5a) and Tankyrase-2 (TNKS2/PARP5b) inhibitor (in vitro auto-PARsylation assay).

Keywords:	4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
Supplier:	AdipoGen Life Sciences
Supplier-Nr:	AG-CR1-3581

Properties

Application:	Potent, reversible cell permeable Wnt pathway signaling inhibitor
MW:	409,4 D
Formula:	C25H19N3O3
Format:	Solid

Database Information

CAS :	1127442-82-3\| Matching products
KEGG ID :	K04385 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+20°C (International: +20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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