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Itopride is an inhibitor of acetylcholinesterase (AChE, IC50 = 1.6 µM for rat stomach enzyme) and a prokinetic agent. It induces contractions in isolated rabbit duodenum when used at concentrations ranging from 1 to 100 µM and enhances ACh-induced contractions in isolated guinea pig stomach circular muscle strips. Itopride (100 mg/kg) enhances normal gastric antral motility and improves gastric antral hypomotility and delayed gastric emptying induced by clonidine (Cay-15949) in rats. Formulations containing itopride have been used in the treatment of functional dyspepsia.Formal Name: N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxy-benzamide, monohydrochloride. CAS Number: 122892-31-3. Molecular Formula: C20H26N2O4 . HCl. Formula Weight: 394.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 213, 259 nm. SMILES: COC1=C(OC)C=CC(C(NCC2=CC=C(OCCN(C)C)C=C2)=O)=C1.Cl. InChi Code: InChI=1S/C20H26N2O4.ClH/c1-22(2)11-12-26-17-8-5-15(6-9-17)14-21-20(23)16-7-10-18(24-3)19(13-16)25-4,/h5-10,13H,11-12,14H2,1-4H3,(H,21,23),1H. InChi Key: ZTOUXLLIPWWHSR-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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