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A mixture of cis-IRIB and trans-ISRIB, trans-ISRIB decreases ATF4-induced increases in gene transcription more effectively than cis-ISRIB in a reporter assay using HEK293T cells (IC50s = 5 and 600 nM, respectively), trans-ISRIB decreases the latency to escape in the Morris water maze and increases the length of freezing time induced by contextual fear conditioning in mice. Formulation: A solid. InChI: InChI=1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,26,28). InChIKey: HJGMCDHQPXTGAV-UHFFFAOYSA-N. SMILES: O=C(COC1=CC=C(C=C1)Cl)NC2CCC(CC2)NC(COC3=CC=C(C=C3)Cl)=O
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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