Isoproterenol (hydrochloride)

Isoproterenol is an agonist of beta1- and beta2-adrenergic receptors (beta1- and beta2-ARs, Kis = 224 and 458 nM, respectively. It is selective for beta1- and beta2-ARs over beta3-ARs (Ki = 1,570 nM). Isoproterenol inhibits contractions in isolated field-stimulated rat vas deferens (EC50 = 45.6 nM). In vivo, isoproterenol (0.33 mg/kg) decreases blood pressure and increases water intake in nephrectomized rats. It reduces blood pressure and increases heart rate in renal hypertensive rabbits. Isoproterenol inhibits histamine-induced bronchospasms in anesthetized dogs. Formulations containing isoproterenol have been used in the treatment of bradydysrhythmias and to improve breathing during anesthesia.Formal Name: 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-1,2-benzenediol, monohydrochloride. CAS Number: 51-30-9. Synonyms: Isoprenaline, NSC 37745, NSC 89747. Molecular Formula: C11H17NO3 . HCl. Formula Weight: 247.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 10 mg/ml, PBS (pH 7.2): 5mg/ml. lambdamax: 225, 282 nm. SMILES: OC1=C(O)C=C(C(O)CNC(C)C)C=C1.Cl. InChi Code: InChI=1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8,/h3-5,7,11-15H,6H2,1-2H3,1H. InChi Key: IROWCYIEJAOFOW-UHFFFAOYSA-N.