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A nonpeptide agonist of PKR1 and PAM of PKR2, increases intracellular calcium release and Akt phosphorylation in PKR1-expressing CHO cells (EC50 = 44 nM), enhances prokineticin-induced ERK phosphorylation in PKR2-expressing CHO cells at 1 nM, increases survival, reduces cardiac lesion formation, improves cardiac function, and increases neovasculogenesis in a mouse model of myocardial infarction at 0.5 mg/kg, i.p.. SMILES: COC(C=C1)=CC=C1/C=C(C(NCC2=CN=CC=C2)=O)\NC(C3=CC=CC=C3)=O. InChi Code: InChI=1S/C23H21N3O3/c1-29-20-11-9-17(10-12-20)14-21(26-22(27)19-7-3-2-4-8-19)23(28)25-16-18-6-5-13-24-15-18/h2-15H,16H2,1H3,(H,25,28)(H,26,27)/b21-14-. InChi Key: KKDANILRTKQMGA-STZFKDTASA-N
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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