Irinotecan
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You can also order by e-mail: info@biomol.com
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA... more
Product information "Irinotecan"
Description: Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand reattachment through binding to the Topo I complex, resulting in double-stranded DNA breaks and cell death. Target: Topoisomerase, Autophagy. Smiles: CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OC(=O)N3CCC(CC3)N3CCCCC3)cc12. References: Keyvani-Ghamsari S, et al. Effect of irinotecan on HMGB1, MMP9 expression, cell cycle, and cell growth in breast cancer (MCF-7) cells. Tumour Biol. 2017 Apr,39(4):1010428317698354.
| Keywords: | CPT-11, Topotecin, (+)-Irinotecan |
| Supplier: | TargetMol |
| Supplier-Nr: | T6228 |
Properties
| Application: | Targets DNA topoisomerase I [EC:5.6.2.1] (TOP1) |
| MW: | 586.68 D |
| Formula: | C33H38N4O6 |
Database Information
| CAS : | 97682-44-5| Matching products |
| KEGG ID : | K03163 | Matching products |
| Protein Atlas Nr. : | Apoptosis, Cell Cycle, DNA Repair |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H315, H318, H361, H373 |
| P Phrases: | P201, P202, P260, P264, P270, P280, P314, P321, P330, P301+P310, P302+P352, P305+P351+P338, P308+P313, P332+P313, P362+P364, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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