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Description: IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-kappaB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 µM, also inhibits TNF-alpha and IL-6 production in vitro. Target: JNK. Smiles: O=C(ON=C1c2ccccc2-c2nc3ccccc3nc12)c1ccco1. References: Schepetkin I A , Kirpotina L N , Khlebnikov A I , et al. Identification and Characterization of a Novel Class of c-Jun N-terminal Kinase Inhibitors[J]. Molecular Pharmacology, 2012, 81(6):832-845.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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