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Item number: Cay44645-10

IQ-3 is a JNK inhibitor. It is selective for JNKs over a panel of 131 kinases at 10 µM. IQ-3 binds to JNKs (Kd = 0. 0. and 0. µM for JNK1-3), as well as casein kinase 1delta (CK1delta), PI3Kgamma, and MAPK-interacting serine/threonine kinase 2 (MKNK2. Kds = 0. 0. and 1. µM, respectively). It also inhibits...

Keywords:	O-(2-furanylcarbonyl)oxime 11H-indeno[1,2-b]quinoxalin-11-one
Application:	JNK inhibitor
CAS	312538-03-7
MW:	341.33 D

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IQ-3

Item number: TGM-T8477-100mg

Description: IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-kappaB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 µM, also inhibits TNF-alpha and IL-6 production in vitro. Target: JNK. Smiles:...

CAS	312538-03-7
MW:	341.32 D

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