Ipsapirone (hydrochloride)

Ipsapirone is a partial agonist of the serotonin (5-HT) receptor 5-HT1A (Ki = 10 nM in hippocampal membranes). It reduces 5-HT release in rat ventral hippocampus in vivo. Low doses of ipsapirone decrease, while high doses increase, extracellular dopamine release in murine nucleus accumbens. Extracellular dopamine levels in murine striatum increase following administration of ipsapirone at concentrations >0.1 mg/kg. Ipsapirone has anxiolytic effects in vivo, inhibiting foot shock-induced aggression and passive avoidance behavior in rats (ED50s = 2.2 and 0.5 mg/kg, respectively). Formulations containing ipsapirone have been used to treat depression and borderline personality disorder.Formal Name: 2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3(2H)-one, 1,1-dioxide, monohydrochloride. CAS Number: 92589-98-5. Synonyms: TVXQ 7821. Molecular Formula: C19H23N5O3S . HCl. Formula Weight: 437.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:40): 0.025 mg/ml, Ethanol: slightly soluble. lambdamax: 236, 284 nm. SMILES: O=S1(N(CCCCN2CCN(C3=NC=CC=N3)CC2)C(C4=C1C=CC=C4)=O)=O.Cl. InChi Code: InChI=1S/C19H23N5O3S.ClH/c25-18-16-6-1-2-7-17(16)28(26,27)24(18)11-4-3-10-22-12-14-23(15-13-22)19-20-8-5-9-21-19,/h1-2,5-9H,3-4,10-15H2,1H. InChi Key: USDUGJXCPKBJTN-UHFFFAOYSA-N.