IPN60090

IPN60090 is an inhibitor of glutaminase 1 (GLS1, IC50 = 0.031 µM for the glutaminase C isoform). It is selective for GLS1 over GLS2 (IC50 = >50 µM), as well as panels of 80 ion channels and receptors and 97 kinases at 10 µM. IPN60090 also binds to zinc finger SWIM domain-containing protein 4 (ZSWIM4, Kd = 2.98 µM). It decreases the viability of A549 non-small cell lung cancer (NSCLC) cells (IC50 = 26 nM) and decreases glycine levels in OVCAR-8 and SKOV3 ovarian cancer cells. IPN60090 (30 mg/kg, p.o.), in combination with the DNA-crosslinking agent carboplatin (Cay-13112), decreases tumor weight and volume in a SKOV3 mouse xenograft model.Formal Name: 4-[(3,3-difluorocyclobutyl)oxy]-N-[6-[(3R)-3-fluoro-4-[4-[(methylamino)carbonyl]-1H-1,2,3-triazol-1-yl]butyl]-3-pyridazinyl]-6-methyl-2-pyridineacetamide. CAS Number: 1853164-83-6. Synonyms: IACS-6274. Molecular Formula: C24H27F3N8O3. Formula Weight: 532.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: FC1(F)CC(OC2=CC(C)=NC(CC(NC3=CC=C(CC[C@H](CN4N=NC(C(NC)=O)=C4)F)N=N3)=O)=C2)C1. InChi Code: InChI=1S/C24H27F3N8O3/c1-14-7-18(38-19-10-24(26,27)11-19)8-17(29-14)9-22(36)30-21-6-5-16(31-33-21)4-3-15(25)12-35-13-20(32-34-35)23(37)28-2/h5-8,13,15,19H,3-4,9-12H2,1-2H3,(H,28,37)(H,30,33,36)/t15-/m1/s1. InChi Key: GEHZIZWHNLQFAS-OAHLLOKOSA-N.