The following products have been found matching your search "K01425": 41

BPTES is an allosteric inhibitor of kidney-type glutaminase 1 (GLS1, IC50 = 3.3 µM) that drives the formation of inactive GLS1 tetramers. It is selective for GLS1 over GLS2, glutamate dehydrogenase, and gamma-glutamyl transpeptidase. BPTES decreases glutaminase activity and reduces proliferation of aerobic P493...

CB-839 is an orally bioavailable noncompetitive inhibitor of the glutaminase 1 (GLS1) splice variants, kidney-type (KGA) and glutaminase C (GAC), which convert glutamine into glutamate. CB-839 inhibits human recombinant GAC with IC50 values of less than 50 nM, varying based on the length of preincubation. It...

This Glutaminase Assay Kit (Colorimetric) is a detection kit for the quantification of Glutaminase activity in cells, bacteria and tissue samples. Protein function: Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates...

Glutaminase inhibitor compound 968 is a cell-permeable, reversible inhibitor of a mitochrondrial glutaminase splice variant, glutaminase C (IC50 = ~2.5 µM), which is commonly found in cancer cells. Through this action, glutaminase inhibitor compound 968 blocks transformation induced by Rho GTPases and inhibits the...

Protein function: Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain (PubMed:30575854, PubMed:30239721,...

Protein function: Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain (PubMed:30575854, PubMed:30239721,...

GLS1 inhibitor is an inhibitor of glutaminase 1 (GLS1, IC50 = 0.021 µM). It inhibits the growth of NCI H1703 non-small cell lung cancer (NSCLC) cells in vitro (GI50 = 0.011 µM). GLS1 inhibitor (100 mg/kg) reduces tumor growth, increases tumor levels of glutamine, and decreases tumor levels of glutamate and aspartate...

Anti-GLS2 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. GLS2 antibody is predicted to not cross-react with other catenin family members. Multiple isoforms of GLS2 are known to exist. Protein function: Plays an important role in the regulation of glutamine catabolism....

Protein function: Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity. [The UniProt Consortium]