- Search results for K01425
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65 products were found matching "K01425"!
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Item number: Cay35855-1
IPN60090 is an inhibitor of glutaminase 1 (GLS1, IC50 = 0.031 µM for the glutaminase C isoform). It is selective for GLS1 over GLS2 (IC50 = >50 µM), as well as panels of 80 ion channels and receptors and 97 kinases at 10 µM. IPN60090 also binds to zinc finger SWIM domain-containing protein 4 (ZSWIM4, Kd = 2.98 µM)....
Keywords: | IACS-6274,... |
Application: | GLS1 inhibitor |
CAS | 1853164-83-6 |
MW: | 532.5 D |
From 240.00€
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Item number: NZY-AE00071
Glutaminase (EC 3.5.1.2) is purified from a recombinant E. coli strain. Glutaminase is an amidohydrolase enzyme which generates glutamate from glutamine. Glutaminase has tissue-specific isoenzymes. Importantly, glutaminase is found in glial cells. Glutaminase is expressed in periportal hepatocytes, where it...
Keywords: | ybaS, b0485, Glutaminase 1 |
Application: | Enzyme assays |
169.00€
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Item number: Cay39883-1
Glutaminase C inhibitor 11 is an inhibitor of glutaminase C (GAC). It inhibits GAC enzyme activity (EC50 = 10.64 nM) and reduces the viability of A549 non-small cell lung cancer (NSCLC) cells (IC50 = 4.025 nM). Glutaminase C inhibitor 11 (0.1 and 1 µM) reduces colony formation by, and intracellular glutamate levels...
Keywords: | (R)-2-(3-phenoxyphenyl)-N-(5-((1-(pyridazin-3-yl)pyrrolidin-3-yl)amino)-1,3,4-thiadiazol-2-yl)acetamide |
Application: | GAC (GLS, Glutaminase kidney isoform, mitochondrial) inhibitor |
MW: | 473.6 D |
From 106.00€
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Item number: ELK-ELK6204.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse GLS2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse GLS2. Next,...
Keywords: | GLS, LGA, Gls2, Kiaa4146, L-glutaminase, L-glutamine amidohydrolase, Glutaminase liver isoform, mitochondrial |
Application: | ELISA |
Species reactivity: | mouse |
From 365.00€
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Item number: Cay22038-5
CB-839 is an orally bioavailable noncompetitive inhibitor of the glutaminase 1 (GLS1) splice variants, kidney-type (KGA) and glutaminase C (GAC), which convert glutamine into glutamate. CB-839 inhibits human recombinant GAC with IC50 values of less than 50 nM, varying based on the length of preincubation. It...
Keywords: | GLS1 Inhibitor III,... |
Application: | Glutaminase inhibitor |
CAS | 1439399-58-2 |
MW: | 571.6 D |
From 77.00€
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Item number: Cay19284-5
BPTES is an allosteric inhibitor of kidney-type glutaminase 1 (GLS1, IC50 = 3.3 µM) that drives the formation of inactive GLS1 tetramers. It is selective for GLS1 over GLS2, glutamate dehydrogenase, and gamma-glutamyl transpeptidase. BPTES decreases glutaminase activity and reduces proliferation of aerobic P493...
Keywords: | N,N'-[thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bis-benzeneacetamide |
Application: | GLS inhibitor |
CAS | 314045-39-1 |
MW: | 524.7 D |
From 43.00€
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Item number: Cay17199-5
Glutaminase inhibitor compound 968 is a cell-permeable, reversible inhibitor of a mitochondrial glutaminase splice variant, glutaminase C (IC50 = ~2.5 µM), which is commonly found in cancer cells. Through this action, glutaminase inhibitor compound 968 blocks transformation induced by Rho GTPases and inhibits the...
Keywords: | 5-[3-bromo-4-(dimethylamino)phenyl]-2,3,5,6-tetrahydro-2,2-dimethyl-benzo[a]phenanthridin-4(1H)-one |
Application: | Glutaminase inhibitor |
CAS | 311795-38-7 |
MW: | 475.4 D |
From 43.00€
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Item number: ARG82767.96
This Glutaminase Assay Kit (Colorimetric) is a detection kit for the quantification of Glutaminase activity in cells, bacteria and tissue samples. Protein function: Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates...
Keywords: | GLS, GLS1 |
Application: | FA |
Species reactivity: | broad |
824.00€
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Item number: AG-CR1-3690-M005
Selective, allosteric non-competitive inhibitor of glutaminase 1 (GLS1), selective for GLS1 over GLS2, glutamate dehydrogenase, and gamma-glutamyl transpeptidase, consequently inhibiting glutaminolysis. Useful agent for immunometabolism research. Glutaminase converts glutamine to glutamate, which is an important...
Keywords: | Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide |
Application: | Selective, allosteric non-competitive glutaminase 1 (GLS1) inhibitor |
CAS | 314045-39-1 |
MW: | 524.7 D |
From 33.00€
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Item number: G-HUFI01447.96
Application: | ELISA |
Species reactivity: | human |
641.00€
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Item number: E-BC-K660-M.96
Detection instrument: Microplate reader. Detection principle: Glutamine is decomposed to produce glutamic acid under the action of glutaminase. Glutamic acid is further transformed by glutamic acid dehydrogenase. Meanwhile, NAD+ is reduced to NADH, Which under the action of hydrogen transmitter, transfer electrons...
Keywords: | GLS, GLS1 |
317.00€
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Item number: ARG55696.100
Protein function: Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity. [The UniProt Consortium]
Keywords: | Anti-GLS, Anti-GLS1, EC=3.5.1.2, Anti-K-glutaminase, Anti-L-glutamine amidohydrolase, Anti-Glutaminase kidney isoform,... |
Application: | WB, IHC (paraffin), ICC, IF, FC |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
584.00€
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