116 products were found matching "K01425"!

In 1X PBS, pH 7.4, with 0.09% sodium azide. Sahai (1983) demonstrated phosphate-activated glutaminase (EC 3.5.1.2) in human platelets. It is the major enzyme yielding glutamate from glutamine. Significance of the enzyme derives from its possible implication in behavior disturbances in which glutamate acts as a...

This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism,...

CB-839 is an orally bioavailable noncompetitive inhibitor of the glutaminase 1 (GLS1) splice variants, kidney-type (KGA) and glutaminase C (GAC), which convert glutamine into glutamate. CB-839 inhibits human recombinant GAC with IC50 values of less than 50 nM, varying based on the length of preincubation. It...

BPTES is an allosteric inhibitor of kidney-type glutaminase 1 (GLS1, IC50 = 3.3 µM) that drives the formation of inactive GLS1 tetramers. It is selective for GLS1 over GLS2, glutamate dehydrogenase, and gamma-glutamyl transpeptidase. BPTES decreases glutaminase activity and reduces proliferation of aerobic P493...

An inhibitor of GLS1 (IC50 = 1 nM), selective for GLS1 over GDH (IC50 = >13 µM), inhibits the proliferation of A549, H22, Caki-1, and HCT116 cancer cells (IC50s = 0.017, 6.78, 0.019, and 0.009 µM, respectively), induces ROS production in A549 cells at 10 µM, decreases tumor weight in an HCT116 mouse xenograft model...

An inhibitor of GAC (IC50 = 0.24 µM), inhibits the proliferation of PC3 and LNCaP prostate cancer cells (IC50s = 6.14 and 2.13 µM, respectively) and non-cancerous CCD-1072Sk fibroblasts (IC50 = 15.39 µM). Formulation: A solid. InChI:...

A GAC inhibitor (IC50 = 29 nM), reduces the proliferation of MDA-MB-231, Hs 578T, and TSE cells (IC50s = 70, 129, and 262 nM, respectively), inhibits replication of SARS-CoV-2 and HCoV-OC43 in Vero and primary HBECs, respectively, at 0.1 µM. Formulation: A solid. InChI:...

JHU083 is a prodrug form of the glutaminase inhibitor 6-diazo-5-oxo-L-nor-leucine (Cay-17580). It decreases tumor volume, increases tumor microenvironment (TME) levels of Tnf-secreting macrophages, and increases survival in a B6CaP murine prostate cancer model. JHU083 increases tumor infiltration by Cd8+ T cells in...

Cayman's Glutaminase Activity Assay Kit provides a convenient method of detecting glutaminase activity in cell lysates and tissue homogenates. Measurement of glutaminase activity is carried out by the Glutamine/Glutamate Developer Enzyme Mix, which detects levels of glutamate produced by glutaminase in the presence...

Glutaminase inhibitor compound 968 is a cell-permeable, reversible inhibitor of a mitochondrial glutaminase splice variant, glutaminase C (IC50 = ~2.5 µM), which is commonly found in cancer cells. Through this action, glutaminase inhibitor compound 968 blocks transformation induced by Rho GTPases and inhibits the...

This Glutaminase Assay Kit (Colorimetric) is a detection kit for the quantification of Glutaminase activity in cells, bacteria and tissue samples. Protein function: Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates...

Selective, allosteric non-competitive inhibitor of glutaminase 1 (GLS1), selective for GLS1 over GLS2, glutamate dehydrogenase, and gamma-glutamyl transpeptidase, consequently inhibiting glutaminolysis. Useful agent for immunometabolism research. Glutaminase converts glutamine to glutamate, which is an important...