Immethridine (hydrobromide)

Immethridine is a potent histamine H3 receptor agonist (Ki = 0.85 nM). It is selective for histamine H3 over histamine H4 receptors (Ki = 245 nM). Immethridine inhibits cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing human H3 receptors (EC50 = 0.18 nM) and induces a concentration-dependent decrease of the electrically induced twitch contraction in isolated guinea pig ileum. In vivo, immethridine (30 mg/kg, s.c.) inhibits hydrochloric acid-induced formation of gastric lesions in rats.Formal Name: 4-(1H-imidazol-5-ylmethyl)-pyridine, dihydrobromide. CAS Number: 699020-93-4. Molecular Formula: C9H9N3 . 2HBr. Formula Weight: 321.0. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Water: soluble. SMILES: C1(CC2=CN=CN2)=CC=NC=C1.Br.Br. InChi Code: InChI=1S/C9H9N3.2BrH/c1-3-10-4-2-8(1)5-9-6-11-7-12-9,,/h1-4,6-7H,5H2,(H,11,12),2*1H. InChi Key: CYNKWHIKNDIVDR-UHFFFAOYSA-N.