Immepip (hydrobromide)

Immepip is a histamine H3 receptor agonist (KI = 0.4 nM in SK-N-MC cell membranes expressing the human receptor). It is selective for histamine H3 over H1 and H2 receptors in CHO cell membranes expressing the guinea pig and human receptors, respectively (Kis = >16 µM for both) but also agonizes H4 receptors (KI = 9 nM in SK-N-MC cell membranes expressing the human receptor). Immepip (5 mg/kg, s.c.) decreases hypothalamic histamine release in anesthetized rats. It decreases flinching in the formalin test in rats when administered at doses of 5 and 30 mg/kg and inhibits formalin-induced paw edema at 30 mg/kg.Formal Name: 4-(1H-imidazol-5-ylmethyl)-piperidine, dihydrobromide. CAS Number: 164391-47-3. Molecular Formula: C9H15N3 . 2HBr. Formula Weight: 327.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble, Water: soluble. SMILES: C1(CC2=CN=CN2)CCNCC1.Br.Br. InChi Code: InChI=1S/C9H15N3.2BrH/c1-3-10-4-2-8(1)5-9-6-11-7-12-9,,/h6-8,10H,1-5H2,(H,11,12),2*1H. InChi Key: YGNJPNRDGXJQJX-UHFFFAOYSA-N.