IFN-alpha-IFNAR-IN-1 (hydrochloride)

IFN-alpha-IFNAR-IN-1 is an inhibitor of the protein-protein interaction between the cytokine IFN-alpha and the IFN-alpha/beta receptor (IFNAR, Kd = 4 µM for binding to IFN-alpha). It inhibits virus-induced increases in the production of IFN-alpha and IL-12 in bone marrow-derived plasmacytoid dendritic cells (BM-pDCs) infected with modified Vaccinia virus Ankara (MVA) or vesicular stomatitis virus (VSV) when used at a concentration of 18 µM. IFN-alpha-IFNAR-IN-1 also reduces increases in IL-12 production induced by stimulation with the toll-like receptor 9 (TLR9) agonist CpG 2216 or the TLR3 agonist poly(I:C) in the same cells.Formal Name: N-methyl-2-(1-naphthalenylthio)-benzenemethanamine, monohydrochloride. CAS Number: 2070014-98-9. Molecular Formula: C18H17NS . HCl. Formula Weight: 315.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 30 mg/ml. lambdamax: 223 nm. SMILES: CNCC1=CC=CC=C1SC2=CC=CC3=C2C=CC=C3.Cl. InChi Code: InChI=1S/C18H17NS.ClH/c1-19-13-15-8-3-5-11-17(15)20-18-12-6-9-14-7-2-4-10-16(14)18,/h2-12,19H,13H2,1H3,1H. InChi Key: QTESJCPDPNGOLF-UHFFFAOYSA-N.