Idarubicin (hydrochloride)

Idarubicin is a 4-demethoxy analog of the leukemia therapeutic daunorubicin (Cay-14159). Both are anthracycline antibiotics which intercalate in DNA and inhibit topoisomerase II, resulting in cancer cell cytotoxicity at low concentrations (IC50 = 20-120 nM for idarubicin). Idarubicin is effective in combination therapy for the treatment of different types of leukemia.Formal Name: (7S,9S)-9-acetyl-7-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione, monohydrochloride. CAS Number: 57852-57-0. Synonyms: 4-Demethoxydaunorubicin, 4-DMD, NSC 256439. Molecular Formula: C26H27NO9 . HCl. Formula Weight: 534.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 252, 287, 482 nm. SMILES: O=C(C1=C2C=CC=C1)C3=C(C(O)=C(C[C@@](O)(C(C)=O)C[C@@H]4O[C@]5([H])O[C@@H](C)[C@@H](O)[C@@H](N)C5)C4=C3O)C2=O.Cl. InChi Code: InChI=1S/C26H27NO9.ClH/c1-10-21(29)15(27)7-17(35-10)36-16-9-26(34,11(2)28)8-14-18(16)25(33)20-19(24(14)32)22(30)12-5-3-4-6-13(12)23(20)31,/h3-6,10,15-17,21,29,32-34H,7-9,27H2,1-2H3,1H/t10-,15-,16-,17-,21+,26-,/m0./s1. InChi Key: JVHPTYWUBOQMBP-RVFAQHLVSA-N.