(±)-Ibuprofen-d3

(±)-Ibuprofen-d3 is intended for use as an internal standard for the quantification of ibuprofen by GC- or LC-MS. (±)-Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) and non-selective COX inhibitor (IC50s = 2.6 and 1.3 µM for human recombinant COX-1 and COX-2, respectively). In vivo, (±)-ibuprofen inhibits late-phase formalin-induced paw licking in mice (ED50 = 6.1 mg/kg). It also inhibits acetic acid-induced writhing in mice (ED50 = 0.47 mg/kg). Formulations containing (±)-ibuprofen have been used in the treatment of fever and mild to severe pain.Formal Name: alpha-(methyl-d3)-4-(2-methylpropyl)-benzeneacetic acid. CAS Number: 121662-14-4. Synonyms: DL-Ibuprofen-d3. Molecular Formula: C13H15D3O2. Formula Weight: 209.3. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: >45 mg/ml, DMSO: >50 mg/ml, Ethanol: >60 mg/ml, PBS (pH 7.2): >2 mg/ml. lambdamax: 212, 219, 263 nm. SMILES: OC(C(C1=CC=C(CC(C)C)C=C1)C([2H])([2H])[2H])=O. InChi Code: InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/i3D3. InChi Key: HEFNNWSXXWATRW-HPRDVNIFSA-N.