Hyperforin (dicyclohexylammonium salt)

Hyperforin is a natural activator of the steroid X receptor (active at 0.1 to 0.5 µg/ml) and inhibitor of several cytochrome P450 (CYP) isoforms (IC50 = 10 µg/ml for CYP2D6). It can also inhibit microsomal prostaglandin E2 synthase-1 (mPGES-1, IC50 = 1 µM), 5-lipoxygenase activating protein, and sirtuins.Formal Name: (1R,5S,6R,7S)-4-hydroxy-6-methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-bicyclo[3.3.1]non-3-ene-2,9-dione, N-cyclohexylcyclohexanamine (1:1). CAS Number: 238074-03-8. Synonyms: Hyp-DCHA, Hyperforin-DCHA. Molecular Formula: C35H52O4 . C12H23N. Formula Weight: 718.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. SMILES: O=C1C(C/C=C(C)/C)=C(O)[C@]2(C(C(C)C)=O)[C@@](CC/C=C(C)/C)(C)[C@@H](C/C=C(C)/C)C[C@@]1(C/C=C(C)/C)C2=O.C3(NC4CCCCC4)CCCCC3. InChi Code: InChI=1S/C35H52O4.C12H23N/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10,1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h13-15,18,26-27,38H,12,16-17,19-21H2,1-11H3,11-13H,1-10H2/t27-,33+,34+,35-. InChi Key: ZUYCAROZOLUHJY-DNSWOBEMSA-N.