Description: Hyperforin dicyclohexylammonium salt is a transient receptor canonical 6 channel activator with antidepressant effect. It modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels. Target: Others. Smiles:...

Hyperforin is a natural activator of the steroid X receptor (active at 0.1 to 0.5 µg/ml) and inhibitor of several cytochrome P450 (CYP) isoforms (IC50 = 10 µg/ml for CYP2D6). It can also inhibit microsomal prostaglandin E2 synthase-1 (mPGES-1, IC50 = 1 µM), 5-lipoxygenase activating protein, and sirtuins.Formal...

Key constituent of St, John's wort, Shows properties of potential pharmacological interest, including anti-bacterial , anti-malarial , anti-inflammatory , anti-cancer and anti-angiogenic effects, Anti-depressant and anxiolytic compound, Specific activator of TRPC6 channels, Inhibits the re-uptake of...

Hyperforin DCHA is a stable salt form of hyperforin, a compound isolated from Hypericum perforatum (St. John's Wort). Hyperforin DCHA exhibits anticancer, anti-inflammatory, and antidepressant activities. In chronic myelogenous leukemia (CML) cells, hyperforin DCHA disrupts the mitochondrial membrane potential,...