(-)-Huperzine A

(-)-Huperzine A is a natural sesquiterpene alkaloid first isolated from Huperzia, a club moss used in Chinese medicine for its neuroprotective activity. It inhibits acetylcholinesterase (AChE) in rat cortex in vitro (IC50 = 82 nM) and displays oral AChE inhibitory activity in animals. (-)-Huperzine A has potential applications in a variety of neuroprotective roles, including protection against organophosphate nerve agents and ameliorating symptoms of Alzheimer's disease.Formal Name: (5R,9R,11E)-5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one. CAS Number: 102518-79-6. Synonyms: Hup A, (-)-Selagine. Molecular Formula: C15H18N2O. Formula Weight: 242.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 20 mg/ml, Methanol: 1 mg/ml. lambdamax: 231, 313 nm. SMILES: N[C@@]1(CC(C)=C2)C(C=CC3=O)=C(N3)C[C@@]2([H])/C1=C\C. InChi Code: InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1. InChi Key: ZRJBHWIHUMBLCN-YQEJDHNASA-N.