HJC0350

HJC0350 is a selective inhibitor of exchange protein directly activated by cAMP 2 (Epac2) with an IC50 value of 300 nM for competition with 8-NBD-cAMP binding. It inhibits Epac2 guanine nucleotide exchange activity but does not inhibit Epac1-mediated Rap1-GDP exchange or cAMP-mediated protein kinase A (PKA) activation in vitro, indicating it is selective for Epac2 at a concentration of 25 µM. HJC0350 also blocks stimulation of Epac2, but not Epac1, by 007-AM in HEK293 cells.Formal Name: 2,4-dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole. CAS Number: 885434-70-8. Molecular Formula: C15H19NO2S. Formula Weight: 277.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 10 mg/ml. lambdamax: 204 nm. SMILES: CC1=C(S(N2C=C(C)C=C2C)(=O)=O)C(C)=CC(C)=C1. InChi Code: InChI=1S/C15H19NO2S/c1-10-6-12(3)15(13(4)7-10)19(17,18)16-9-11(2)8-14(16)5/h6-9H,1-5H3. InChi Key: AFZWZVLPIMHLSE-UHFFFAOYSA-N.