Description: HJC0350 is an effective and specific EPAC2 inhibitor (IC50: 0.3 µM), and no inhibition of Epac1. Target: cAMP. Smiles: Cc1cc(C)n(c1)S(=O)(=O)c1c(C)cc(C)cc1C. References: Chen H, et al. J Med Chem. 2013, 56(3), 952-962.

HJC0350 is a selective inhibitor of exchange protein directly activated by cAMP 2 (Epac2) with an IC50 value of 300 nM for competition with 8-NBD-cAMP binding. It inhibits Epac2 guanine nucleotide exchange activity but does not inhibit Epac1-mediated Rap1-GDP exchange or cAMP-mediated protein kinase A (PKA)...