HIF-2alpha Translation Inhibitor 76

HIF-2alpha translation inhibitor 76 is an inhibitor of hypoxia-inducible factor-2alpha (HIF-2alpha) translation. It inhibits constitutive gene expression in a hypoxia-response element (HRE) reporter assay using VHL-deficient 786-O renal cell carcinoma (RCC) cells (IC50 = 5 µM). HIF-2alpha translation inhibitor 76 reduces the translation of nascent HIF-2alpha mRNA in 786-O cells. Conditioned medium from 786-O cells preincubated with HIF-2alpha translation inhibitor 76 inhibits the proliferation of human umbilical vein endothelial cells (HUVECs). HIF-2alpha translation inhibitor 76 (10 nM) inhibits erythrocytosis and angiogenesis induced by DMOG (Cay-71210) in zebrafish. It increases survival and right ventricle contractility and inhibits right ventricle hypertrophy in a rat model of pulmonary arterial hypertension induced by monocrotaline (Cay-16666).. Solulibility: DMSO: Soluble: =10 mg/ml: .