Hexestrol-d6

Hexestrol-d6 is intended for use as an internal standard for the quantification of hexestrol (Cay-29003) by GC- or LC-MS. Hexestrol is a synthetic non-steroidal estrogen receptor ligand that binds to estrogen receptor alpha (ERalpha) and ERbeta (Kis = 0. and 0. nM for the human and rat receptors, respectively). It inhibits rat liver microsomal and ox brain phospholipid liposomal lipid peroxidation (IC50s = 1. and 2. µM, respectively). It also inhibits porcine microtubule assembly and induces disassembly of preformed microtubules when used at concentrations of 50 and 100 µM, respectively, in a cell-free assay. Hexestrol (25 mg/animal) induces kidney tumors in male Syrian hamsters.. Solulibility: DMSO: Slightly soluble: Methanol: Slightly soluble.