GW 8510

GW 8510 is an inhibitor of cyclin-dependent kinase 2 (Cdk2) and Cdk5 (IC50s = 3, 3, and 7 nM for Cdk2/cyclin E, Cdk2/cyclin A, and Cdk5/p25 complexes, respectively). It is selective for Cdk2 and Cdk5 over Cdk1/cyclin B, Cdk4/cyclin D, Cdk7/cyclin H, and Cdk9/cyclin T (IC50s = 49, 139, 317, and 543 nM, respectively). It also decreases ribonucleoside-diphosphate reductase subunit M2 (RRM2) levels and induces autophagy in HCT116 colon cancer cells when used at a concentration of 4 µM. GW 8510 (1-500 nM) protects against MPP+-induced cytotoxicity in primary human neural progenitor cells derived from induced pluripotent stem cells (iPSCs) in an in vitro model of Parkinson's disease. In vivo, GW 8510 (2 mg/kg) increases grip strength and gastrocnemius and soleus muscle-to-body weight ratios in a mouse model of muscle atrophy induced by sciatic nerve denervation. InChI: InChI=1S/C21H15N5O3S2/c27-21-15(19-16(25-21)8-9-17-20(19)30-12-24-17)11-23-13-4-6-14(7-5-13)31(28,29)26-18-3-1-2-10-22-18/h1-12,23H,(H,22,26)(H,25,27) InChIKey: GCYXEGSPUDSZJY-UHFFFAOYSA-N SMILES: O=S(NC1=NC=CC=C1)(C2=CC=C(NC=C(C3=C(N4)C=CC5=C3SC=N5)C4=O)C=C2)=O