GW 1929

Peroxisome proliferator-activated receptor (PPAR) gamma is a nuclear receptor that, when activated, regulates fatty acid storage and glucose metabolism. The best known class of PPARgamma ligands are the thiazolidinediones, including troglitazone (Cay-71750) and rosiglitazone (Cay-71740). GW 1929 is a non-thiazolidinedione activator of PPARgamma that binds with a Ki value of 1.4 nM, with greater than 1,000-fold selectivity over other PPAR subtypes. It has anti-hyperglycemic and anti-hyperlipidemic activity when given orally in mouse and rat models of type 2 diabetes. Both in vitro and in vivo effects of GW 1929 on PPARgamma greatly exceed those produced by troglitazone. In addition, GW 1929 has neuroprotective effects in global cerebral ischemic-reperfusion injury that are related to reduced inflammation and apoptotic DNA fragmentation.Formal Name: N-(2-benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine. CAS Number: 196808-24-9. Molecular Formula: C30H29N3O4. Formula Weight: 495.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 20 mg/ml. lambdamax: 245 nm. SMILES: O=C(C1=CC=CC=C1)C(C=CC=C2)=C2N[C@H](C(O)=O)CC3=CC=C(OCCN(C4=CC=CC=N4)C)C=C3. InChi Code: InChI=1S/C30H29N3O4/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23/h2-18,27,32H,19-21H2,1H3,(H,35,36)/t27-/m0/s1. InChi Key: QTQMRBZOBKYXCG-MHZLTWQESA-N.